It is the first of such ventures by a major US hotel group since the Cuban revolution in 1959.
The new hotel offers 348 rooms and suites, a contemporary design and a fitness center.
100 Sheraton hotels will get the Sheraton Grand branding by 2017.
The World Luxury Index Hotels report 2013 shows that Hilton Worldwide, Jumeirah, Fairmont and Shangri-La are among the most sought after brands for luxury travellers.
For travelers looking for a healthy getaway, here are a few good places to stay along the way.
Sheraton is the most sought-after luxury hotel brand on the Internet in mainland China, followed by Hilton and Shangri-La.